Two sample MR report
LY86_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.2735373 | 0.1141514 | 0.0961969 |
| Weighted median | 5 | -0.0824500 | 0.0269471 | 0.0022156 |
| Inverse variance weighted | 5 | -0.0667900 | 0.0229491 | 0.0036101 |
| Simple mode | 5 | -0.0854044 | 0.0332587 | 0.0621180 |
| Weighted mode | 5 | -0.0832551 | 0.0302279 | 0.0511510 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.296407 | 3 | 0.7299865 |
| Inverse variance weighted | 4.693752 | 4 | 0.3201875 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.1552745 | 0.0842423 | 0.1625214 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005141 | 0 | TRUE | 0.0312778 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
